Expedient Synthesis of a Modular Phosphate Affinity Reagent
نویسندگان
چکیده
منابع مشابه
Synthesis and biological evaluation of phosphatidylinositol phosphate affinity probes.
The synthesis of the complete family of phosphatidylinositol phosphate analogues (PIPs) from five key core intermediates A-E is described. These core compounds were obtained from myo-inositol orthoformate 1 via regioselective DIBAL-H and trimethylaluminium-mediated cleavages and a resolution-protection process using camphor acetals 10. Coupling of cores A-E with phosphoramidites 34 and 38, deri...
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ژورنال
عنوان ژورنال: Bioconjugate Chemistry
سال: 2010
ISSN: 1043-1802,1520-4812
DOI: 10.1021/bc900538b